Posted by Mistermindmasta on November 29, 2005, at 1:59:31
In reply to Another interesting study involving IL-1, posted by Tomatheus on November 27, 2005, at 23:38:19
Sounds like this studies shows no association between the il-1 gene and ADHD, but studies in the past did.
This is another good abstract however, in that it's saying that ADHD could be caused by a reaction to increased IL-1, which modulate noradrenergic activity. I believe this is the future of ADHD and what it's really about. Well, not necessarily that IL-1 causes ADHD but this general direction is where the exciting stuff is gonna be.
I imagine a scenerio where, for example, studies find that people with certain genetics and increased (unknown?) fungal populations in the gut will respond by inappropriately releasing IL-1, which their brain inappropriately responds by cutting out NE and DA function... just an example of the type of research I am expecting in the future...
> FYI...
>
> ABSTRACT:
>
> Replication test for association of the IL-1 receptor antagonist gene, IL1RN, with attention-deficit/hyperactivity disorder.
>
> Misener VL, Schachar R, Ickowicz A, Malone M, Roberts W, Tannock R, Kennedy JL, Pathare T, Barr CL.
>
> Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ont., Canada.
>
> Attention-deficit/hyperactivity disorder (ADHD) has a strong genetic basis, and aberrant brain dopaminergic and noradrenergic activity is implicated in its etiology. Interleukin-1 (IL-1), its antagonist, IL-1Ra, and IL-1 receptors are all present in the brain, and IL-1 has been shown to influence both dopaminergic and noradrenergic function. Recently, Segman et al. [1] tested the IL-1Ra gene, IL1RN, as a candidate for involvement in ADHD.Using the transmission/disequilibrium test (TDT) to examine 77 nuclear ADHD families for the inheritance of alleles of an intronic 86-bp VNTR polymorphism, they found significant evidence for biased transmission of the 4-repeat allele (p=0.04) and non-transmission of the 2-repeat allele (p=0.03). Here, we sought to replicate this in an independent sample of families. In contrast to the previous findings, our analysis of 178 ADHD families showed no evidence for biased transmission of these alleles (p=0.81 and p=1.00, respectively). Our lack of evidence for association of this IL1RN polymorphism with ADHD, based on a much larger sample of families, suggests that the original finding may have been a spurious (i.e. false-positive) result. These findings highlight the need for further investigations of this marker, in additional independent ADHD samples, in the future. Copyright 2004 S. Karger AG, Basel
>
> LINK TO FULL ARTICLE (PDF):
> http://www.twinsandmultiples.org/adhd/misener2004.pdf
>
> Tomatheus
poster:Mistermindmasta
thread:582826
URL: http://www.dr-bob.org/babble/20051126/msgs/583231.html