Posted by SLS on February 20, 2006, at 12:48:41
In reply to Re: NRIs are infact dopamine uptakin inhibitors ? » zeugma, posted by SLS on February 20, 2006, at 9:34:00
> I guess the bottom line is that NE uptake inhibitors help to regulate the "tone" of dopaminergic neurons by sweeping up their mess for them.
I said that wrong.
I meant to say that the NE uptake transporter pumps located on noradrenergic neurons act as brooms to sweep up the mess left by the release of dopamine from dopaminergic neurons; a mess for which the dopaminergic neurons are ill equiped to handle for themselves.
> If the brooms break [drug-induced NE uptake transporter inhibition], the tone of DA neurons increases, leading them to become more easily stimulated by the messages they are meant to propogate.
Sorry.
Steven Stahl, MD, has a good handle on this stuff.
- Scott
poster:SLS
thread:611154
URL: http://www.dr-bob.org/babble/20060219/msgs/611411.html