Posted by mike99 on February 25, 2006, at 17:29:01
In reply to Re: provigil discussion, posted by tessellated on February 25, 2006, at 14:42:49
>> As far as the specifics, "direct or indirect alpha-adrenergic agonist" does not necessarily include "auto-adrenergic receptor (modulation)", as these structures are presynaptic and located in the axon not at the synaptic cleft where most neurotransmission occurs.
Good point--the monograph states "At pharmacologic concentrations, modafanil does not bind to MOST POTENTIALLY RELEVANT receptors for norepinephrine, serotonein, dopamine..."
Whatever "most potentially relevant" means. Not very informative IMHO.
> Notice they don't even mention beta adrenergic activity.
They sure don't.
Ditto's on wishing there was more to go on.
poster:mike99
thread:612884
URL: http://www.dr-bob.org/babble/20060219/msgs/613261.html