Posted by mike99 on February 25, 2006, at 20:55:34
In reply to Re: provigil discussion, posted by tessellated on February 25, 2006, at 20:15:32
..rs
This may likely be to what your doc was referring.
In the CNS alpha-2 receptors are presynaptic autoreceptors.
Stimulating this receptor by NE or drugs such as clonidine or tenex inhibits NE release (presynaptically), which theoretically should result in decreased activation of the corresponding post-synaptic noradrenergic receptors.
Antagonizing the same receptor by a drug like remeron/mirtazapine conversely results in increased NE release.
To the best I could gather, the 2006 PDR still states provigil is not an agonist or antagonist at any "potentially relevant receptors for NE, etc...". I think this would, or at least should include the alpha-2 autoreceptor.
poster:mike99
thread:612884
URL: http://www.dr-bob.org/babble/20060219/msgs/613323.html