Posted by SLS on March 16, 2006, at 11:23:33
In reply to Re: Never thought I'd hear this....., posted by linkadge on March 16, 2006, at 10:56:49
Hi.
The links you gave here seem to be very helpful. Thanks. I'll have to look at them later.
Again, I think that the majority of manic reactions to antidepressants are indicative of a bipolar diathesis and that using amphetamines in animals is not a valid reproduction of this process.
- Scott
> I am aware of some animal models of mania. Rapid cycling, for instance, could easily be detected in animal. (Ie. they are hyperactive/hypersexual for days, and then seem to crash and not move for days)
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> I do know that there are big bucks put into reasearch nowadays to see how SSRI's can influence these behaviors, as well as influencing genes that have been linked with instability.
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> I know that there are animal models used which are often sucessfull at findind potential mood stabalizing agents. A dexamphetamine-chlordiazepoxide model was used to identify keppra as a potential mood stabilizer.
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> Methamphetamine is often used to replicate an animal model of mania with psychotic features.
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> There is some evidence that the GRK3 (G protein receptor kinase) enzyme is involved in mania, and perhaps psychosis. Expression is elevated in mania, and the state is readily reproducable in mice by administration of stimulants (don't know about antidepressants)
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> PACAP is another (enzyme?) that is influcenced oppositly by antidepressants and mood stabalizers, and is under investigation.
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> http://neurotransmitter.net/bipolargrk3.html
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> Pertaining to SSRI induced mania and rapid cylcing.
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> http://neurotransmitter.net/admania.html
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> Linkadge
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poster:SLS
thread:620137
URL: http://www.dr-bob.org/babble/20060315/msgs/620921.html