Posted by mattye on December 14, 2006, at 14:13:28
In reply to Do APs block the euphoric effects of opiates?, posted by Quintal on December 14, 2006, at 8:49:28
It is interesting that you brought this up, because I was wondering the same thing about SSRIs blocking the effect of opiates.
As a seasoned opiate abuser, I was surprised that when I took 5 40mg oxycontins, chewed up, (that's 200mgs!) I barely got high. I was drinking too! It had been weeks since I used an opiate drug, so I should have had no tolerance. My brother took one and got high as hell and was throwing up! I have always had some intrinsic tolerance towards opiates, but this was ridiculous! The only thing I could think of was that I had recently started on Lexapro about 2 months earlier. Perhaps the SSRI made some changes in my brain - dopamine depletion or something.
The other weird thing is that I am SUPER sensitive to stimulants. I hate them! I took one of my sister's adderall the other day and I wanted to scratch my eyes out. I think my brain is already wired too fast and speed just makes my thoughts feel out of control.
poster:mattye
thread:713536
URL: http://www.dr-bob.org/babble/20061212/msgs/713641.html