Posted by Quintal on December 16, 2006, at 18:26:22
In reply to Re: Do APs block the euphoric effects of opiates?, posted by Vale on December 16, 2006, at 14:02:39
>Low doses of certain A.P's act as disinhibitors and reduce blunted affect states.
(Sulperide, Amisulpride).That statement could be slighty misleading because low doses of amisulpride and sulpiride (the two are closely related) have the *opposite* effect on D2 receptors to other APs. They are agonists at low doses and work in a similar way to cabergoline et al. D2 agonists can cause hallucinations and other psychotic behaviour so they are not used at low doses for the same purposes as other APs (to manage psychosis, subdue aggressive behaviour etc). There has been suggestion of their use in cocaine detox. Much of this implies that conventional APs are powerful dysphoriants.
>Correct doses of traditional A.P's suit many patients,they actually reduce stereotype behaviour while sheilding them from stress and allowing better ability to concentrate on things.
It's true that low dose benzos at least can appear to give the illusion of increased concentration (I've experienced this myself) as the person becomes less preoccupied with his/her internal worries and pays more attention to the outside world. It wasn't until I withdrew from these drugs that I realised just how much my normal responses had really been impaired though. It seems unlikely that a person's concentration on APs would be better than their concentration than while they are stable and unmedicated though.
>Have you ever been in the company of someone dosed up to their eyeballs with Heroin, they're not exactly the life and soul of the party either.
Ah, you're talking about sociability there and that's not what we are referring to. Obviously someone is going to be more sociable on APs, well, less anti-social at least, than someone who is actively psychotic. It is the typical dysphoric effect of APs and the way they negate the subjective sensation of euphoria and well-being produced by opiates that was the original topic of the thread.
>It all boils down to what suits the individual and at the ideal dosage. In any event though, they should be reserved for serious illness, opiate addiction doesn't qualify, unless it's associated with psychosis.
I agree.
Q
poster:Quintal
thread:713536
URL: http://www.dr-bob.org/babble/20061212/msgs/714352.html