Posted by Larry Hoover on January 20, 2007, at 13:50:46
In reply to kindof unhelpful if effexor is not included :( (nm), posted by iforgotmypassword on January 20, 2007, at 2:16:41
From the receptor affinity database:
http://kidb.cwru.edu/pdsp.phpDopamine Transporter Ki (nM) for various substrates mentioned in this thread (range):
Ritalin 21-50
Adderal no values for any amphetamines
Zoloft 22-315 (latter value is an outlier; all others similar to Ritalin)
Wellbutrin 520-950
Tranylcypromine 5100 (single value)
Effexor 3070-9300
Paxil 268-963It should also be noted that there are a number of pharmakokinetic parameters influencing the relative effect of these meds at this transporter, including dose, molecular weight, bioavailability, first pass metabolism, and CNS uptake, to say nothing of genetic influences. Also, as mentioned, active metabolites are not considered here (but many are listed in the above database, if you know what they are).
Lar
poster:Larry Hoover
thread:724214
URL: http://www.dr-bob.org/babble/20070119/msgs/724465.html