Posted by halcyondaze on January 20, 2007, at 14:42:24
In reply to Zoloft and dopamine reuptake inhibition, posted by Quintal on January 20, 2007, at 14:19:43
The chart I refer to from the Psychiatry book was exclusively on dopamine reuptake inhibition.
There's another chart with regard to blockade of DA receptors, in which the affinity is as follows:
Amoxapine: approx 5.5
Trimipramine: approx 0.5
Clomipramine: approx 0.5
Remeron: approx 0.2
Serzone: approx 0.2
And less than 0.1: Imiprimine, Amitriptyline, Nortriptyline, Desipramine, Doxepin, Protriptyline. Less than 0.01 is Prozac, Luvox, and Trazodone.It really depends on what mechanism you're looking at.
These charts have relative potencies at therapeutic dosing ranges but, without explanation as to the exact mechanism of each drug, are very difficult to compare.
> From the receptor affinity database:
> http://kidb.cwru.edu/pdsp.php
>
> Dopamine Transporter Ki (nM) for various substrates mentioned in this thread (range):
>
> Ritalin 21-50
> Adderal no values for any amphetamines
> Zoloft 22-315 (latter value is an outlier; all others similar to Ritalin)
> Wellbutrin 520-950
> Tranylcypromine 5100 (single value)
> Effexor 3070-9300
> Paxil 268-963
>
> It should also be noted that there are a number of pharmakokinetic parameters influencing the relative effect of these meds at this transporter, including dose, molecular weight, bioavailability, first pass metabolism, and CNS uptake, to say nothing of genetic influences. Also, as mentioned, active metabolites are not considered here (but many are listed in the above database, if you know what they are).
>
> Lar
poster:halcyondaze
thread:724214
URL: http://www.dr-bob.org/babble/20070119/msgs/724510.html