Posted by linkadge on May 28, 2007, at 14:05:36
In reply to Re: I'm confused., posted by deniseuk190466 on May 28, 2007, at 12:10:15
This still may not be a contradiction. There are postsynaptic and presynaptic receptors for 5-ht1b.
The presenyaptic receptors are autoreceptors. By downregulating the presynaptic 5-ht1b autoreceptors, you diminish the inihibition on serotonin release, and thus promote more serotonin release.
The postsynaptic 5-ht1b receptors are controlled by p11, and activation of these receptors may be responsable for AD effect. So p11 increasing the expression of these receptors might be benificial.
So it may have been that one study was referring to the downregulation of 5-ht1b autoreceptors, wherase the other was referring to the increase in post-synaptic 5-ht1b receptors.
Linkadge
poster:linkadge
thread:759830
URL: http://www.dr-bob.org/babble/20070524/msgs/760003.html