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Re: Could someone give me some cites on that, plea » Honore

Posted by GWA on June 28, 2007, at 19:48:44

In reply to Re: Could someone give me some cites on that, plea, posted by Honore on June 28, 2007, at 18:42:48

Irritatingly, I can't find the free abstract I originally read. However -

http://www.jbc.org/cgi/content/full/276/18/15107:
"carbonyl reactive reagents... react with the aldehyde group of PP [pyridoxal phosphate] and thereby block its coenzyme activity. These agents include hydrazines, which form hydrazones (examples are 1-amino-D-proline in linseed oil and several drugs, including the anti-tuberculous agent isoniazid, carbidopa, phenelzine, and hydralazine)"

PDRHealth says of B6 that "Phenelzine may react with pyridoxal 5'-phosphate to yield a metabolically inactive hydrazone compound".

The abstract I'm thinking of said, essentially, not "may" but "does". Anyway, my experience of sharp decline with discontinuation symptoms, not at the time recognised as such, after taking B6, and then of recovery beginning about ten days after dropping it, is proof enough for me.

I don't know about Parnate, I'm afraid.


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