Posted by linkadge on July 23, 2007, at 13:38:37
In reply to Re: SSRI brain damage » linkadge, posted by Racer on July 23, 2007, at 12:02:00
This was an interesting study:
http://www.come-over.to/FAS/tianeptine.htm
Note, the author makes the destinction that his results *cannot* be extrapolated to other antidepressant agents.
There are tons of other studies however. Typing something along the lines of "tianeptine + neuroprotective" will likely yeild many results.
I have thought about combining melatonin with an SSRI. I think ones best bet would be to use a short acting SSRI (perhaps paxil) at as low a dose as possable (in the morning), and to combine it with some sort of 5-ht2a antagonist in the evening. (5-ht2a antagonists appear to reverse the 5-ht2a mediated supression of cortisol release).
The only caution is, that melatonin may actually reverse the antidepressant effect of fluoxetine and desipramine!
See: (look under heading: Antidepressant medications)
http://www.adam.com/democontent/IMCAccess/ConsSupplements/Melatonincs.html
My own personal theory on that is that the antidepressant effect of the SSRI's is acutally mediated by alteration of sleep cycles. Perhaps, by normalizing sleep patterns, melatonin actually blocks the mechanism of these antidepressants.
Linkadge
poster:linkadge
thread:771164
URL: http://www.dr-bob.org/babble/20070719/msgs/771370.html