Posted by Larry Hoover on July 24, 2007, at 8:31:50
In reply to Re: SSRI brain damage, posted by linkadge on July 23, 2007, at 9:43:50
> SSRI's for instance, show only weak ability to protect against cortisol induced glutamate toxicity. Some studies I have come across show an exaserbation of stress induced glutamatergic neurotoxicity. SSRI's can also often lead to long term increases in cortisol levels.
>
> Indeed, the following study shows that fluoxetine worsens the effect of escape restraint stress on neuronal placticity.
>
> http://www.jneurosci.org/cgi/content/full/22/9/3638....during exposure. I don't mean to sound argumentative, but the issue for me would be whether the stress reaction rebounded to more normal parameters after the drug had worn off.
> Some other considerations are the following: SSRI's can decrease melatonin levels. Melatonin has strong neuroprotective capacity, and lowering its levels may have negative consequences on neuronal health.
>
> There have been hints that both the SSRI's and lithium may increase the risk of developing parkinsons. There is a study showing that patients treated with SSRI's develop neuroanatomical changes in the thalamus.
>
> http://www.jneurosci.org/cgi/content/full/22/9/3638You inadvertently pasted in the same link for the first paper.
> Other possabilities including increasing lipid peroxidation by lowering the seizure threshold. Apparently sertraline has the ability to increase lipid peroxidation by a pro-convulsant mechanism.
>
> See:
>
> http://www.ijp-online.com/article.asp?issn=0253-7613;year=2004;volume=36;issue=1;spage=42;epage=43;aulast=RizwanThe researchers do not report the dose of sertraline. Moreover, it appears to have been injected. At best, the concerns are suggestive for further research. I know of no link between sertraline and seizure in humans.
> SSRI's will enhance neurogensis in certain hippocampal subfeilds. Other neurotransmitters are involved in hippocampal placticity too however. Acetylcholine, dopamine, norepinephrine etc all promote neurogenesis in certain brain regions. Boosting serotonin too high may enhance neurogenesis in certain brain regions at the expense of other brain regions.
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> Just my own personal thoughts.
>
>
> LinkadgeI'm really concerned by certain interpretations of studies like these. Time-dependent regulatory changes are not evidence of damage.
This is my philosophy of science I'm applying. Empirically, I see no evidence of anything I would call damage, here.
Lar
poster:Larry Hoover
thread:771164
URL: http://www.dr-bob.org/babble/20070719/msgs/771580.html