Posted by B2chica on November 14, 2007, at 8:59:59
Sigma-1 receptor
for those that don't want to read the whole thing.
my question is, how is the sigma-1 receptor different from the DA receptors...is it dopamine effecting?
do the same meds that are used for DA receptors used with the sigma receptor? and is there much research on it?
and i would like to learn more about experiences of psychotic depression...any websites..or personal experiences i'd like to know..
thanks.NOW for the Long version:
i've been doing some reading about the 5-ht2 receptor and DA receptors.
several years ago i was Dx with Bipolar2...i new i've always had depression but i had a friend that was truly Bipolar and just never quite felt like i fit....the 'episodes' that i would describe to my (prev) docs would say i was manic...a dysphoric mania...maybe so. ..but the more i've been reading lately, i feel that i fit better in the descriptors of psychotic depression.
i hadn't even heard of this descriptor before.
here is what they generally list:
-anxiety
-agitation
-aggression
-hypochondria
-insomnia
-physical immobility
-constipation
-cognitive impairment
-psychosisi've suffered from 8 of those.
the docs kept asking (re: mania) do you ever feel REALLY good....well, i have but i always tell them i will be severly depressed then i feel really good for about 2 days and then it turns "dysphoric" using their terms. it could get pretty severe....extreme rage, soon turning inward, i'd hear this kinda voice in my head telling me nasty things and sometimes acting on them....i several times spun into a severe psychotic episode (delusional thinking...not like i think famous actor loves me or something but i believe people can hear my thoughts, or my inner voice warns me of things/people...etc.)....the docs kept telling me its mania..i later switched to a differend pdoc (i really liked him), he was never convinced that i was bipolar but never told me anything else.
lately during therapy and stopping breastfeeding my depression has come back with a vengance.
this time im keeping track of all my "oddities". and it seems that when i see my shadow things and hear things it's during the lowest of my depressive phase, EVEN though i feel Energized....it's not a good energy. it makes me shaky and scared and angry and i just want to "hurt myself very badly" to remain civil.
quite frankly i get "wacked out". but it happens During my depressive phase.back to above questions.
thank you for listening
b2c
poster:B2chica
thread:795027
URL: http://www.dr-bob.org/babble/20071104/msgs/795027.html