Posted by linkadge on November 15, 2007, at 22:17:29
In reply to Re: Sigma-1 receptor/Psychotic Depression Ques... » B2chica, posted by Astounder on November 15, 2007, at 19:52:17
Fluvoxamine has shown stronger effiacy in psychotic depression than other SSRI agents. I think there was the presumption that its binding for sigma receptors had something to do with this.
Sigma receptors inteact with nerve growth factor to produce certain trophic actions in neurons. Sigma receptors appear to be capable of mediating antidepressant effects on their own.
The mood elevating effects of DHEA might be a mediated by sigma receptors as DHEA binds to sig-1r. But then again, DHEA is no antipsyhotic!
Many of the typtical antipsychotics are antagonists at sigma receptors, so this confuses the model as fluvoxamine is an agonist.
Sigma 1r receptor agonism appears to have some nootropic activity, which may mediate the effectiveness of fluvoxamine in psychotic depression. I read destinct theory that regarding the activity of sig-1r receptors on brain lipid metabolsm which may be of relavance to mood disorders.
Linkadge
poster:linkadge
thread:795027
URL: http://www.dr-bob.org/babble/20071115/msgs/795378.html