Posted by Nardilstarted2007 on November 24, 2007, at 21:15:59
In reply to Re: Some would rank Nardil No. 1 for SAD » Nardilstarted2007, posted by medweirdo on November 24, 2007, at 15:03:31
> > Medweirdo, Most often when using Nardil you want to get to your theraputic dosage as soon as possible. BUT without uping the dose so quickly that your body cant adapt and you get intolerable side effects. I'd say if you've been on 15mg for a week and the side effects arent too bad, go up to 30 and see how that feels for a week. You said your really sensitive to meds and side effects so doing slow titration may be the way for you. Side effects are something you must live with at the beginning but they get better as time goes on (much better) . see how fast you can titrate up to 45 mg's per day (1 pill three times a day) If you can tolerate the side effects then GREAT! Thwn just keep slowly upping your dose if no theriputic responce is felt after a week or two. If the side effects are too bothersome then lower the dose back to the previous dose you were on and stay there a little while longer before adding another 15 mgs. The target dose is 1mg/kg of body weight, Thats an old rule of thumb but stil works. you may feel better at just 30 mgs/day or 45 or 60. some people go up to 90. I was soo desperate I didn;t listen to my doctor and thru away the dose paper. I just started at 75mgs/day and have been there for 6 weeks. I dont suggest anyone ever do that especially you if your sensitive to drugs, but just to say steadily increase your dose as long as you can tolerate the side effects. 60mgs/day is usually where people get the theraputic effect - it doest really matter when you take your pills, but most people do half in the morning and half in the afternoon, or many variations. I take 2 in the morning, 2 in theafter noon and one during the evening.
> >
> > I dont know why I blabbled on for so long!! seems like that message is saying the same thing 3x in a row.. well im foggy this morning because I had to take a sleeping pill last night due to nardil induced insomnia.
> >
> > Good Luck, Keep asking Questions, Others will be here soon with more input.
> >
> > NardilStarted
>
> Thank you Nardilstarted. the case is that I've been on 15mg for 4 days without any SE. are there people who gets the SE right after 1 or 2 dose?
>
> Do you think I can up my dose to 30mg a day and see how I respond after being on 15mg for 4 days?Hello Medweirdo, I've read so so much about nardil and other maoi's that I'm very glad to share what I've learned. I did so much studying on them because i was at the end of my rope and was obsessed to find the med that would work, Nardil is probably No. 1 for SP, Phobias and OCD and maybe depression. I take it for SP. I think you should be just fine to go to 30mgs for a week. If you get side effects that are untolerable go back to 15mg's for another week before trying 30 again. And Yes I you can feel some side effects after just a day or two just from the chemical itself. The other thing that gives you side effects is when Nardil really starts to inhibit mao. So the chemical = side effect and mao inhibition = side effects. Nardil usually takes a week before it inhibits mao to the max for whatever dosage your on (I bet 15 mgs/day wont inhibit very much, maybe 30% mao). Some people feel really bad right away just from the chemical, some dont. Some start to feel bad SE after a couple weeks once the Nardil has inhibited enough mao so that there is an increas in seratonin, Norepinepherine and Dopamine because this will alter many functions in your body. At a dosage of 1mg/kg of body weight per day, nardil should inhibit about 80% mao. AND thats where some serious side effects can kick in because you have so much DA (dop) NE (norepineph) and 5-HT (seratonin) then usual. This is what you want to acheive to get the therapeutic effect. SE's vary alot between individuals. I felt very sluggish for the first 2 weeks and heavy, poor cognative skill and a weird dizzyness which all went away by week 3.5 I knew that after one weeek at 75mgs I had achieved about 80% mao inhibition as I could feel the effects of increased neurotransmitters. but it took 2 weeks after that for it to work. And my SE's have changed to insomnia, anorgasmia and I have to follow the dietary restrictions to a point, Thats how I knew I hit good mao inhibition. For the first week I could ejaculate just fine and eat anything and sleep which ment it took 1 week to get the inhibition to 80% ish at 75mgs/day. Just because you hit enough mao inhibition doesn't mean youll start feeling better right away, it takes a few weeks for it to kick in even if you are at 80% mao inhibition. since I started at 75mg's per day I had fully enough mao ihibition after week 1 but felt no respoce till two weeks after that, making a total of three weeks. If you titrate slowly it takes a lot longer to work because you have to achieve the mao inhibition you need, then wait for it to kick in.
I think your safe to try 30 for a week 1 pill in morning, one around noon. Then if you can try 45mgs for a week or two, 1 pill in morning one at noon and one at evening. If no goodness is felt there and you can tolerate 60 mgs then try 60 mgs for another couple weeks. Who knows how much you'll need just keep ramping it up if you can tolerate it until you feel it kick in then wait there and it should do its magic. I hear it gets even better with time once you hit your magic dose, But im going to ask that on another post. If I don't get more responce in another few weeks I might try 90mgs/day.. Side effects for me are getting much better except insomnia.
I know this was a long post, ces't la vie. I'll try and get better at doing shorter posts.
NardilStarter
poster:Nardilstarted2007
thread:795876
URL: http://www.dr-bob.org/babble/20071115/msgs/796890.html