Posted by cumulative on November 29, 2007, at 17:29:53
In reply to Re: On Trivastal Again. Feeling soooooooo goood.. » Mishal, posted by clipper40 on November 29, 2007, at 17:19:41
Trivastal is not prescribed for depression -- Mishal is using it off-label, as I shortly will be doing as well. A D1/D2/D3 agonist with additional alpha-2 adrenergic activity and stable blood levels over 24 hours, I believe it has tremendous potential in conditions that are linked to poor dopaminergic function -- such as ADD, and anergic depression. It's a French drug used (only) in Parkinson's disease and has been noted to have particular use in improving inattention, apathy, anhedonia -- these three probably the cornerstones of my psychiatric troubles.
Mishal takes 50mg/daily IIRC; I have the opportunity of using up to 250mg/daily (a dose used in Parkinson's monotherapy) if I so choose, but I imagine I'll be taking a lower dose.
What I plan is: I will also try to acquire an alpha-2 agonist such as clonidine (preferably guanfacine, but I need to find a source) to offset Trivastal's adrenergic effects in the evening and allow me to get full sleep, and perhaps a dose in the morning as well. Though I respond very well to dopaminergics, I do not tolerate strong adrenergic effects very well, hence my problems with psychostimulants. I'm not sure how strong this stimulation from Trivastal is, so we'll see.
In addition, I may be adding additional items, such as Lyrica (pregabalin) for sleep quality (which I think Mishal tried as well).
Updates forthcoming!
poster:cumulative
thread:797558
URL: http://www.dr-bob.org/babble/20071125/msgs/797663.html