Posted by clipper40 on November 29, 2007, at 23:55:49
In reply to Re: On Trivastal Again. Feeling soooooooo goood.., posted by cumulative on November 29, 2007, at 17:29:53
> Trivastal is not prescribed for depression -- Mishal is using it off-label, as I shortly will be doing as well. A D1/D2/D3 agonist with additional alpha-2 adrenergic activity and stable blood levels over 24 hours, I believe it has tremendous potential in conditions that are linked to poor dopaminergic function -- such as ADD, and anergic depression. It's a French drug used (only) in Parkinson's disease and has been noted to have particular use in improving inattention, apathy, anhedonia -- these three probably the cornerstones of my psychiatric troubles.
>
> Mishal takes 50mg/daily IIRC; I have the opportunity of using up to 250mg/daily (a dose used in Parkinson's monotherapy) if I so choose, but I imagine I'll be taking a lower dose.
>
> What I plan is: I will also try to acquire an alpha-2 agonist such as clonidine (preferably guanfacine, but I need to find a source) to offset Trivastal's adrenergic effects in the evening and allow me to get full sleep, and perhaps a dose in the morning as well. Though I respond very well to dopaminergics, I do not tolerate strong adrenergic effects very well, hence my problems with psychostimulants. I'm not sure how strong this stimulation from Trivastal is, so we'll see.
>
> In addition, I may be adding additional items, such as Lyrica (pregabalin) for sleep quality (which I think Mishal tried as well).
>
> Updates forthcoming!
We have many of the same issues: inattention, apathy, anhedonia and I don't tolerate noradrenergics easily. Don't know yet how I will respond to dopaminergics but I'm guessing it will be well. I'm very interested in hearing how you do on this medication and especially how severe the noradrenergic effects are.Good luck and thanks for your response!
poster:clipper40
thread:797558
URL: http://www.dr-bob.org/babble/20071125/msgs/797758.html