Posted by bleauberry on December 10, 2007, at 18:49:26
In reply to Trivastal day 1, posted by elanor roosevelt on December 9, 2007, at 19:14:31
I know about half-lives from experience with mercury chelation using DMSA. This relates to trivastal, so bear with me. People who take DMSA once, twice, or 3 times a day get worse. That's because as the drug wears off, mercury that has not yet been excreted gets re-deposited in the body. Redistribution. Poisoned all over again. The mercury has to go all the way from the body to the toilet, and the only way to do that is to maintain a steady level of DMSA, which means taking it every 4 hours around the clock...including setting an alarm to wake up in the middle of the night for a dose.
Trivastal taken every two hours at 4mg per dose would come out to 50mg for a 24 hour period. That would accomplish the same steady blood level as the timed release. Timed release is not a factor in how the drug works, it is a convenience because people just do not want to take multiple doses throughout a day. Or people might forget doses. The timed release just makes it much easier, more user friendly, and more marketable. If you can cut the pill into 12 fairly equal pieces, or crush it to a powder and divide it into 12 fairly equal piles, you would have a workable strategy. But you gotta stick to the every two hour dose. You could probably skip the night doses if you wanted to and just take it during the day.
If someone really wants to try the drug, but they are senstive, scared, or worried of side effects, taking 4mg every 2 hours is a way to go. Or if really sensitive and scared, take 2mg every 2 hours.
poster:bleauberry
thread:799798
URL: http://www.dr-bob.org/babble/20071204/msgs/800005.html