Posted by SLS on May 5, 2008, at 5:01:11
In reply to SAMe Combined with Antidepressants., posted by bleauberry on May 4, 2008, at 18:07:47
I am just wondering, though, if Deplin might actually produce a greater concentration of S-AMe in the locales necessary to produce an antidepressant effect. Deplin pours through the blood-brain barrier unhampered. The other advantage to using Deplin is that its methylation processes consume homocysteine.
Alpert et al. are great investigators of clinically applicable issues.
- Scott> Came across this at pubmed. It was interesting to see that adding a large dose of SAMe to ssri did not result in serotonin syndrome, and did result in 43% remission of people who had not adequately responded to ssri alone. Despite the usual disclaimer at the bottom indicating a placebo controlled trial is warranted, this small trial did pretty good. I mean, to get a 50% response and 43% remission from any group with one augmentation effort is unusually good.
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> Depression Clinical and Research Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA. jalpert@partners.org
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> BACKGROUND: The purpose of this open trial was to evaluate the safety, tolerability, and efficacy of oral S-adenosyl-L-methionine as an antidepressant adjunct among partial and nonresponders to serotonin reuptake inhibitors or venlafaxine. METHOD: Thirty antidepressant-treated adult outpatients with persisting major depressive disorder received 800 to 1600 mg of S-adenosyl-L-methionine tosylate over a 6-week trial. RESULTS: Intent-to-treat analyses based on the Hamilton Depression Rating Scale revealed a response rate of 50% and a remission rate of 43% following augmentation with S-adenosyl-L-methionine. Gastrointestinal symptoms and headaches were the most common side effects. CONCLUSION: Augmentation of selective serotonin reuptake inhibitors or venlafaxine with S-adenosyl-L-methionine warrants a placebo-controlled trial in resistant depression.
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> PMID: 15538131 [PubMed - indexed for MEDLINE]
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poster:SLS
thread:827188
URL: http://www.dr-bob.org/babble/20080430/msgs/827277.html