Posted by BrightEyed+Blueberry on May 7, 2008, at 22:08:07
In reply to Re: EMSAM works 4 those w/ amphetamine mood elevation?, posted by undopaminergic on May 7, 2008, at 21:18:04
I don't understand how selegiline is metabolized into amphetamine and methamphetamine and that stuff is racing around in the bloodstream and NOT effecting you? I guess it's not making it up into the brain and saturating synapses, receptors, dopamine transporters, whatever?
EMSAM is not meant for ADD in any way, right? What about to promote executive functioning: memory, motivation...I've gathered some feel it can extend your life....
Just musings and wonderings....
BTW, thanks, I didn't know--geez, what's in a name?!--(amphetamine = Alpha-MethylPHenylEThylAMINE).
Learn something new everyday!
-Bright
***the metabolites> > Will selegiline or EMSAM tend to work for those people suffering depression who respond to amphetamine with mood elevation?
> >
> > I thought this excerpt interesting, specifically regarding 1) selegiline, 2) sample "subjects responded to amphetamine with mood elevation," and 3) atypical depression/soft signs of bipolarity:
> >
> > "The combination of the selective MAO type B inhibitor L-deprenyl (selegiline) with LPA rapidly relieves depression in a significant number of patients,50 including 6 of 10 patients with drug-resistant major depressive disorder. Our sample was biased in that subjects had treatment-resistant depressions, responded to amphetaminewith mood elevation, and had reduced urinary FAA. Our subsequent clinical observations indicate that perhaps as many as one-fourth of depressed patients, particularly those with atypical depression or soft signs of bipolarity,
> > show substantial improvement with L-deprenyl (10 mg/ day), LFA (1-6 g), and pyridoxine (100 mg), the vitamin required as coenzyme for ecarboxylation. Currently, we
> > use this combination often as initial treatment because it can rapidly be tested for effectiveness and has a minimum of side effects."
> >
> > Phenylethylamine Modulation of Affect:
> > Therapeutic and Diagnostic Implications
> > Hector C. Sabelli, M.D., Ph.D., Javaid I. Javaid, Ph.
> > (The Journal of Neuropsychiatry and Clinical
> > Neurosciences 1995; 7:6-14)
> >
> > Anyone have any thoughts? I've been on EMSAM for 6 weeks and it started to work right away on my atypical depression (and yes done the SSRIs/Wellbutrin/Effexor rigamarole for 10 years),and I am someone who has responded with positive mood elevation in the past to insufflated street-procured methamphetamine (not everyone does--I never liked/felt "good" from cocaine, for instance).
> >
>
> It seems very logical that those responding with mood elevation to amphetamine would respond favourably to selegiline, as selegiline inhibits the MAO-B enzyme that breaks down endogenous (or exogenous) phenylethylamine (PEA), which is similar to amphetamine in action (amphetamine is Alpha-MethylPHenylEThylAMINE). If selegiline on its own proves insufficient, it can be boosted with phenylalanine or PEA supplements.
poster:BrightEyed+Blueberry
thread:827789
URL: http://www.dr-bob.org/babble/20080430/msgs/827846.html