Posted by SLS on May 9, 2008, at 12:02:15
In reply to Re: Wonder Why Wellbutrin was So Bad - Me too. » SLS, posted by johnj on May 9, 2008, at 8:29:29
> Scott,
>
> If that was the case with NE wouldn't you react the same way to nortriptyline?Not necessarily. I personally do not believe that the NE or DA reuptake inhibition of Wellbutrin is significant enough to account for its long-term efficacy. It seems to be through an indirect pro-NE property that NE activity is potentiated.
I wish I could remember the details of the international symposium on the mechanism of action of Wellbutrin that took place several years ago. Even that think-tank couldn't come up with an answer.
I think one of the most important factors accounting for the varied reactions to similar drugs is that they are dissimilar in where they act in the circuitry of the brain.
As an example, I respond to some degree to imipramine, desipramine, and nortriptyline, but I am made very much worse by protriptyline and reboxetine. All of these drugs are NE reuptake inhibitors. Go figure.
- Scott
poster:SLS
thread:828024
URL: http://www.dr-bob.org/babble/20080430/msgs/828180.html