Posted by iforgotmypassword on December 14, 2008, at 10:49:18
In reply to Re: Eplivanserin - new sleep med, posted by Sir Dugald on December 14, 2008, at 10:32:33
but we have yet to try such a selective 5-ht2a antagonist or inverse agonist, so it is hard to speculate what it's side effects may be.
it has comparable affinity to the the 5-ht2c where it is an simple antagonist (not an inverse agonist), but how that translates into occupancy, i don't know.
the effects of this drug on executive function, apathy and anhedonia, EPS (especially SSRI induced EPS, "RLS", and every type of long term EPS), and general functionning, will be something to watch out for.
i am seriously considering ziprasidone, but despite it's high selectivity for 5-ht2a (by several times over D2), it's occupancy of D2 is still high. i am particularly worried about this because risperidone gave me a scary feeling that it was supressing my breathing.
i worry that we may see another case of a french drug being too interesting for the united states, and therefore also its dependency to its north, to let through.
poster:iforgotmypassword
thread:868280
URL: http://www.dr-bob.org/babble/20081214/msgs/868711.html