Posted by psychobot5000 on December 16, 2008, at 22:26:34
In reply to Re: Eplivanserin - new sleep med, posted by Sir Dugald on December 14, 2008, at 10:32:33
> Hey you psychopharmacologists out there. Do you know why eplivanserin will be a non-sedating sleep aid when Mirtazapine which is also a Serotonin 2 blocker is unbelievably sedating?
Though the H1 thing has already been noted in other posts, I just wanted to add that Mirtazipine's H1 effects are apparently extremely powerful, comparable to doxepin's. Apparently, taking mirtazipine's like walking around under a triple dose of benadryl all day, at least in terms of the antihistamine effects.
Of course it also increases noradrenaline. Big, complicated drug.
poster:psychobot5000
thread:868280
URL: http://www.dr-bob.org/babble/20081214/msgs/869181.html