Posted by karl on December 19, 2008, at 15:15:07
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by desolationrower on December 19, 2008, at 13:39:59
i haven't taken amineptine. servier doesn't make it anymore and the only place i've seen it is on www.biopsychiatry.com where this pearce guy is pushing it pretty hard, at a premium markup since it's only made in small batches by a private laboratory.
from the way amineptine is described, it sounds like it feels like it's somewhere between wellbutrin and ritalin/cocaine on the "upper" spectrum. how did you find it?
i think selegiline confuses people because they don't understand which sensations are caused by which of its two actions. since it is both metabolized into meth AND inhibits mao-b, people have a hard time figuring out which of the two is doing what to them and at what times. i certainly have difficulty discerning and understanding the various feelings.
but if people are interested in seeing what pure mao-b inhibition feels like with a minimum of side effects, they should know that, like i said before, 2.5mg oral selegiline hydrochloride once per day is enough to inhibit 95% of the enzyme. again, that's according to this study.
and d/r, i want to take back taking back what i said earlier about selegeline's metabolism.
selegiline under the tongue [citrate or hydrochloride are the same thing, people ought not be fooled; the base doesn't matter.] is more invigorating because more selegiline is absorbed into the bloodstream than orally [wikipedia says 4.4% of the selegiline one swallows is absorbed into the bloodstream, i have no data on how much is absorbed sublingually, though it's certainly more], therefore more is converted into meth.
you're right in saying that sublingual selegiline doesn't undergo first-pass metabolism, but it is still readily metabolized by the liver whenever it gets there. and sublingually, it gets there quickly.
you're right, not through the portal vein, but through the "hepatic artery, a branch of a main heart artery called the aorta, which brings oxygenated blood from the heart to the liver. Sometimes up to a quarter of all the blood in the body is circulating through the liver."
source: http://www.cpmc.org/advanced/liver/patients/topics/liver-function.html
it seems like there's a lot of confusion out there about selegiline's action because of 1) its numerous properties [meth metabolites, mao-b inhibition, antioxidant] and 2) modes of delivery [tablet, liquid, patch] that entities of varying moral caliber have cooked up and it would be nice to have someone who really knows what they're talking about [unlike myself] clear up the matter on this board so that people who search for information on the once-simple selegiline molecule have something reliable to go on as they try to make themselves feel better so they don't have to listen to the [aptly named] GarbageMan. or me.
poster:karl
thread:825078
URL: http://www.dr-bob.org/babble/20081214/msgs/869665.html