Posted by psychobot5000 on December 21, 2008, at 16:08:20
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » psychobot5000, posted by Marty on December 21, 2008, at 1:15:03
>
> 5-HT2c antagonism is activating, especially just before bed which is the case with Agomelatine. So activating as to become an obstacle to sleep.
>
> Apart from Prozac and Agomelatine, most 5-HT2c antagonist usually benefit from some 5-HT2a antagonism which, contrary to 5-HT2c ANT, is very pro sleep.> As I don't believe in DA antagonism in the treatment of depression, I'd go with low dose Trazodone
> /\/\arty
>Many thanks, all. The 2c receptors seem to have some paradoxical effects (don't they?), and I was hoping to hear a bit from people about them.--I found this from some study or other:
"This notion is supported by findings that 5-HT2C receptor antagonists stimulate dopaminergic and adrenergic pathways, exert antidepressant and anxiolytic actions in behavioural paradigms, and favour sleep and sexual function."
Sounds great--every one of those effects would be a positive for most depressives, wouldn't they? I suppose the only way to find out how Agomelatine or another antagonist will work (with or without other 5ht2-affecting meds like Traz.), is a personal trial. Glad to hear yours is going so damned well, Marty.
Regards,
Psychbot
poster:psychobot5000
thread:869924
URL: http://www.dr-bob.org/babble/20081214/msgs/870115.html