Posted by Marty on January 19, 2009, at 15:15:54
In reply to Atypical APs with lowest SRI - for AD augment, posted by psychobot5000 on January 18, 2009, at 10:42:09
Leveling Agomelatine night 5-ht2c antagonism with Geodon/Zeldox during the day is quite a good ideal Psychobot ! .. I wonder how you had this brilliant idea ;)=No credit at all ? damn.. I knew I should have put a patent on that idea ! =)
Btw, I'll report soon how effective it is.. but I can confirm the only negative point at this time: I can feel the SSRI effect on my sexuality, but ----VERY--- subtely .. and I suspect it would go away after sometime, even for me which is insanely SRI sensitive. It's worth a try if you can put your hand on some Geodon. Take 1/4 of a 40 mg capsule and you'll have an idea of what it can give you right away./\/\arty
> Hi all,
>
> Been looking up atypical antipsychotics for potential antidepressant augmentation. The best bets seem to be, based on receptor binding affinities, abilify (for its distinctive d2 effects and relatively low side-effect profile) and geodon/ziprasidone. Possibly also olanzapine.
>
> For my purposes (I'm looking for 5ht-2c blockade with few side-effects), ziprasidone/Geodon seems the obvious choice. Based on what I've read, it has the best 5ht-2c binding of atypical APs, with relatively low risks of sedation (H1 binding) and metabolic disorders. Taken at low doses (i.e. 20mg), it could hit 5ht2a and 2c without really affecting D2, they say. However, some sources claim it has a substantial SRI effect (which is anathema to me). Anyone know anything about this, specifically how its SRI effect compares to other APs--and nefazodone? I don't do well with serotonin reuptake inhibition--it gives me nasty side-effects--but I believe I need something with substantial 5ht-2c antagonism (to augment and 'balance' my night-time dose of agomelatine during the day). Anyone know what the best antipsychotic (or other med) for 5ht2c blockade--with lowest relative serotonin reuptake inhibition might be? Or even just how low-dose ziprasidone's numbers might compare with low-dose nefazodone's (i.e. which is likely to have the lowest SRI)
>
> Currently I'm trying around 100mg nefazodone per day, and while it seems to be helpful, it has some fairly unpleasant SSRI-like side-effects (i.e. sweating all night), even though nefazodone's SRI effect is relatively modest.
>
> Thanks for any input,
> Psychobot5000
>
poster:Marty
thread:874727
URL: http://www.dr-bob.org/babble/20090104/msgs/874982.html