Posted by Marty on January 19, 2009, at 15:48:38
In reply to Re: Atypical APs with lowest SRI - for AD augment » psychobot5000, posted by SLS on January 18, 2009, at 17:34:02
BTW... for anyone interested in researching about dopamine and the prefrontal cortex regions ...(5-HT2c antagonism is mainly thought to be about that by inhibiting Gaba circuitry between 5-HT2c receptors and DA neurons in this region of the brain: disinhibiting DA release.)
... here's a fascinating fact: the prefrontal cortex regions DOESN'T have any kind DA transporter! .. DA diffused itself far from its secretion site and is eventually taken cared of by NET (NorEpinephrine transporters) which possess a stronger affinity for DA than for NE itself! A consequence of this is an increase of synaptic NE since NET are occupied by more DA than usual.
Just saying.. I hope I'm not the only geek which find this fascinating :)
Side note: I had to stop my Wellbutrin for Agomelatine to work: just like with Tianeptine, Wellbutrin was somehow strangely antagonizing the effect .. Wellbutrin being a weak NET/DAT inhibitor, the fact I reported is one pretty interesting in my case !
/\/\arty
poster:Marty
thread:874727
URL: http://www.dr-bob.org/babble/20090104/msgs/874990.html