Posted by linkadge on January 26, 2009, at 17:56:05
In reply to Blood BDNF reflects brain: Potential Treatment, posted by SLS on January 26, 2009, at 16:58:42
>Levels of the factor in blood decreases during >manic or depressive episodes in proportion to >severity.
I have heard the opposite (that BDNF levels are elevated in mania (and lower in depression)
http://www.journals.elsevierhealth.com/periodicals/ymehy/article/PIIS0306987703002974/abstract
Also see:http://www.accessmylibrary.com/coms2/summary_0286-35145560_ITM
"Lithium significantly decreased BDNF levels in patients with BD and healthy control participants, although BDNF levels remained lower (33%) in the BD group posttreatment. Conclusion: Decreased BDNF may constitute part of the pathophysiologic process of BD in a lithium-responsive subgroup of individuals with this disease."
>Because BDNF tends to normalize with effective >treatment and euthymia, BDNF levels may be a >useful tool and biomarker of active bipolar >illness.I don't necessarily think so. See the above study. There are others like it.
Clozapine and typicals lower BDNF:
Risperidal Lowers BDNF:
http://www.ncbi.nlm.nih.gov/pubmed/10861791?dopt=Abstract
Epival and Phyntoin decrease BDNF:
Ketamine improves depresson but does not increase BDNF:Chronic Stress induces depression in mice without affecting BDNF levels.
Neither desipraminem, prozac or nardil increse hippocampal BDNF levels
etc. etc.>People with lower BDNF have smaller hippocampii. >The hippocampus is responsible for memory (among >other things).
Show me a study which proves this.
Linkadge
poster:linkadge
thread:876377
URL: http://www.dr-bob.org/babble/20090104/msgs/876394.html