Posted by bleauberry on April 21, 2009, at 17:27:50
In reply to Severe insomnia, considering Percocet, posted by G-man885858 on April 19, 2009, at 1:48:40
Ok then, I've been following this thread. The clues are popping up.
What is happening is we have been looking in all the wrong places. We've been looking in the places that make the most sense, yes, but in your case those are the wrong places.
We've been focusing on stuff like benzo-like actions, antihistamine-like actions, dopamine blocking-like actions. All make perfect sense. Usually.
So what does makes sense when those things don't work? To me, from personal experience and observation of others, that is easy.
Norepinephrine.
Yikes. Norepinephrine? Isn't that like adrenaline? Isn't that like the opposite of sedative?
Well, in simplistic theory, maybe. In a stimulant action where norepinephrine is released, that is not what you want. That is one of the things Seroquel does. But in a reuptake inhibition action of norepinephrine, now you have just entered a totally different ballpark. Now you've got all kinds of feedback mechanisms kicking in that modulate hypo or hyper adrenals, which in turn modulates thyroid, and on downstream effects everything else.
Here are some different strategies for you to try that make a ton of sense, at least to me. Based on my own experience and observations of others...
Amitriptyline 10mg-25mg (3 hours before bed)
The new drug Savella 25mg-50mg (split once at breakfast and once in mid-afternoon).
Savella caused me, and does most people, worsening of insomnia in the early days, with a profound improvement of sleep kicking in within a week. It is not a sedative.
It somehow resets things so the sleep mechanisms work. You actually get sleepy when you are supposed to, and you sleep deep like you are supposed to, without taking a sedative to do it. And those don't work for, so even mentioning them is a mute ridiculous pursuit anyway.
Up to this point, you've only been focusing on the sedatives, and they haven't worked. That is already a dead-end road. Pure logic. It is a different mechanism, real simple. It aint benzo, it aint histamine, and it aint dopamine.
No joke. Put those two meds at the top of your list before thinking of anything else.
poster:bleauberry
thread:891531
URL: http://www.dr-bob.org/babble/20090416/msgs/891979.html