Posted by desolationrower on April 24, 2009, at 14:26:56
In reply to Bleauberry » bleauberry, posted by G-man885858 on April 23, 2009, at 16:57:33
ACK. While i think NA might be important, i'm not sure a reuptake is what you need. And desip is only a NRI, nothing else. IMO just reducing NA or especially Alpha1 activation is a good idea for sleep, so clonidine would be my reccomendation. Amytr. like bb said i also think would help, it has alpha1 blocking, and is an antihistamine, and the antimuscarinic might help too. Additionally, hte meds that cause you problems all increase 5ht. Blocking 5ht2 receptors would be a good idea; it improves deep sleep. amytr. does this, but desipramine doesn't. the biggest side effect of those nasty TCAs is somnelence. get rid of the other sides, get rid of the sleep aid. desip might help you not feel so tired during the day though, or possibly normalize alpha1 activity or something.
Basically, i'd go: cyproheptadine maybe up to 20mg or mirtazapine 15mg-30mg probably (h1/5ht2 blocking), add clonidine (alpha1 blocking, alpha2 agonist to decrease na), then a benzo/z-drug. also gabapentin might help too. i'd also use melatonin and magnesium. if you haven't, learn some meditation. it helped me fall asleep faster because i learned to clear my mind when i went to bed.
-d/r
poster:desolationrower
thread:891531
URL: http://www.dr-bob.org/babble/20090416/msgs/892530.html