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Re: Little more » linkadge

Posted by SLS on May 14, 2009, at 6:23:44

In reply to Re: Little more » SLS, posted by linkadge on May 13, 2009, at 20:21:06

> Check out this study.
>
> http://www.ncbi.nlm.nih.gov/pubmed/17429410?ordinalpos=41&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
> Linkadge


Thanks.

Interesting. That is the second abstract I have seen that casts doubt on the need for 5-HT1a receptor upregulation to produce an antidepressant response.

It is an easy argument to make that the probable heterogeneity of diatheses of phenotypic depressions allows for multiple mechanisms to be contributory to a therapeutic effect across the population. Post mortem studies of humans with MDD have demonstrated reduced 5-HT1a binding.

There are so many different reported biological correlates of Axis I affective disorders, it is difficult to invest in any one of them.

- Scott

 

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