Posted by SLS on May 20, 2009, at 5:00:29
In reply to Re: This study makes no sence, posted by SLS on May 20, 2009, at 4:51:53
> > > http://www.biomedexperts.com/Abstract.bme/16477619/Early_social_enrichment_augments_adult_hippocampal_BDNF_levels_and_survival_of_BrdU-positive_cells_while_increasing_anxi
> > >
> > > Linkadge> > Maybe there is a lack of neuronal pruning in an environment where there is too much stimulation.
> > I almost forgot that when rats are placed in an overcrowded environment, their behavior becomes dysfunctional. This is a consistent finding. I would have to research exactly what are the resultant behaviors, but they do become hostile and fail to mate for breeding.----------------------------
This following study reports some very salient findings:
1. The overcrowding paradigm does reliably produce depressive behavior in rats.
2. Swimming-induced head twitching in rats in the forced swimming test represents a new marker for depression and drug studies.
3. Antidepressants work.
:-)
- Scott
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http://www.ncbi.nlm.nih.gov/pubmed/1479766
1: Keio J Med. 1992 Dec;41(4):221-4.Links
"Swimming-induced head twitching" in rats in the forced swimming test induced by overcrowding stress: a new marker in the animal model of depression?
Naitoh H, Nomura S, Kunimi Y, Yamaoka K.Department of Psychiatry, Fujita Health University, School of Medicine, Aichi, Japan.
We have used overcrowding stress to study the pathogenesis of depression and the action of antidepressant drugs. In the present study, the influence of overcrowding on behavior was assessed by the forced swimming test. All the stressed rats revealed highly characteristic head twitching movement, which was not inhibited by repeated administration of diazepam and haloperidol, but was markedly suppressed by repeated administration of desipramine and mianserine. A significant positive correlation in the number of twitching episodes in each stressed rat between the first and second forced swimming test was seen. These findings support the use of overcrowding of rats as a stressor in the animal depression model because it fulfills the criteria of the model; face validity, construct validity and predictive validity. We propose the adoption of "swimming head twitching" as a new marker in the animal model of depression.
- Scott
poster:SLS
thread:896668
URL: http://www.dr-bob.org/babble/20090515/msgs/896757.html