Posted by Brainbeard on July 17, 2009, at 5:02:46
In reply to Re: Intrusive OCD thoughts? » Brainbeard, posted by yxibow on July 17, 2009, at 1:52:52
> Huh.... 1A2 / 2D6 (p450) I think I'm guessing...Luvox very strongly inhibits 1A2, which is why it boosts caffein so badly. It hardly touches 2D6. It also very strongly inhibits 2C19; strongly inhibits 2C9; and is a moderate inhibitor of 3A3/4. 2C19 is very important for clomipramine's metabolism; 1A2 and 3A4 are important too, and 2D6 plays a minor role.
> No... I've been through a lot of things.... Anafranil is doing something for my OCD perhaps a little more than Luvox but like I said, the NE makes me more nervous now. Your biochemical imbalance never is a constant thing....
'With gradually increasing dosing of clomipramine the plasma concentrations of desmethylclomipramine (noradrenergic action) is 40-85% higher than the concentration of clomipramine at a dose level of 75 mg/day' (Eriksson E. Strong but non-selecitve serotonin re-uptake inhibition: the unique profile of clomipramine. Anafranil (clomipramine); Past, present and future, a product profile. Basel: Ciba-Geigy 1994; 86-93).
> I was on high dose Luvox before... quite high... it is true that it actually is good for OCD, it wasn't 100% a marketing strategy.Agreed, though it should have been marketed as an antidepressant as well. Luvox' specificity for OCD may be due to its action on sigma-1 receptors, or its potent (and literally nauseating) stimulation of 5HT3-receptors, which eventually leads to desensitation of these receptors which will result in 'defacilitation' of dopamine. Just like ondansetron does with its direct 5HT3-antagonism.
poster:Brainbeard
thread:903596
URL: http://www.dr-bob.org/babble/20090709/msgs/907192.html