Posted by SLS on July 18, 2009, at 9:31:18
In reply to Re: Intrusive OCD thoughts?, posted by Brainbeard on July 18, 2009, at 7:55:45
> Memantine.. Almost never heard of it.. I saw someone using it a while ago on this forum.. [Does some quick googling] Memantine, my friend, is an N-methyl-D-aspartic acid glutamatergic receptor antagonist. That's right. So, how can it help with OCD? Well, I would say by attenuating glutamatergic hyperactivity (http://ajp.psychiatryonline.org/cgi/content/full/162/11/2191-a).
From what I remember reading, OCD might involve pathological glutamatergic pathway looping. Perhaps this perpetual looping is the result of insufficient "braking" of these pathways by serotonergic modulation, probably afferent from the Raphe Nuclei. That's my guess, anyway.I hope you stick around. I find your input to be very valuable.
- Scott
poster:SLS
thread:903596
URL: http://www.dr-bob.org/babble/20090709/msgs/907325.html