Posted by SLS on July 27, 2009, at 5:15:04
In reply to Re: Nortriptyline Bust, posted by bleauberry on July 26, 2009, at 19:01:40
> > > Not cool. Hanging on by threads.
> >
> > Is there any possibility that using such a low dosage of nortriptyline is producing paradoxical effects such that they would be reversed upon reaching standard therapeutic dosages?
> >
> > I imagine you will be too scared to try raising the dosage at this point, and I would hate to recommend something that is going to make you feel worse. Which other drugs have produced this same syndrome?
> Deeply increased depression is not a side effect, as I see it.No, but it could be part of a cluster of other symptoms that represent an untoward drug reaction syndrome. Knowing this might yield a clue as to what to avoid in the future.
> The dry mouth, lack of appetite, those are side effects. Deeply increased depression tells me wrong drug wrong person. So you did experience these other things?
Yes. I have never had a drug start off making me feel worse and then go on to make me feel better. However, at such minute dosages, perhaps there is just enough NE reuptake inhibition to turn off synthesis and release via presynaptic receptor stimulation without producing enough for postsynaptic neuronal concentrations to produce action potentials. I believe that presynaptic autoreceptors are of a higher affinity for ligand than postsynaptic receptors. Just a whacky posit...
As with Linkadge, I hate for you to miss out on TCA. The notion of a biphasic reaction to TCA is really wishful thinking on my part.
> Picture a bone thin significantly underweight person at 132 pounds 6 feet tall. Now picture them 6 weeks later at 122 pounds.
Which drug or drugs have produced this kind of weight loss?
> Since the weight loss has been so severe in an already frail skinny patient, we'll never know the outcome of what might have happened at higher doses, except that the patient might have died from anorexic conditions trying to find out, if suicide didn't do it first.Understood.
> 2. Remeron + ??? (Milnacipran maybe???) (and Ritalin???) HHmmm. That has possibilities.
Sounds hopeful.
Good luck and keep thinking.
- Scott
poster:SLS
thread:908611
URL: http://www.dr-bob.org/babble/20090721/msgs/908785.html