Posted by iforgotmypassword on August 30, 2009, at 16:54:35
is seems that it changes depending on the region of the brain.
in the striatum, it is a straight antagonist. it seems that it has more instances of straight post-synaptic antagonism than partial agonism, only really being an agonist at autoreceptors.
not a settling trait.
in terms of increasing VTA dopaminergic function, it's strong 5-ht1a partial agonism is also spoiled by it's D2 partial agonism, agonising D2 autoreceptors, cutting off VTA dopminergic projections severely, and perhaps causing akathisia very similarly to how SSRIs do.
poster:iforgotmypassword
thread:914905
URL: http://www.dr-bob.org/babble/20090826/msgs/914905.html