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Re: Buspirone vs Pindolol » tensor

Posted by SLS on September 1, 2009, at 6:54:47

In reply to Buspirone vs Pindolol, posted by tensor on September 1, 2009, at 6:38:55

> What are your experiences with these as augmentors in treating depression? Is one of them to prefer?
>
> /Mattias


Buspirone has more potential to be effective as an augmenter of antidpressants. I guess you already know that buspirone and pindolol do opposite things at 5-HT1a receptors. Pindolol has been reported to speed-up the response to SRI drugs, but does not increase the response rate. Buspirone does. You need to take into consideration that buspirone has a major metabolite that acts as a NE alpha2 antagonist, a property shared with mirtazapine (Remeron). You get two drugs in one with buspirone.


- Scott

 

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