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Re: Tandospirone

Posted by mtdewcmu on December 30, 2009, at 23:10:27

In reply to Re: Tandospirone, posted by SLS on December 30, 2009, at 13:45:07

> Tandospirone and gepirone are both azapirones that act as 5-HT1a partial agonists. I have always thought that gepirone would make a better augmenter of antidepressants than it is a monotherapeutic tool to treat depression. The same might be true of tandospirone. One thing that is rarely mentioned about these drugs (buspirone, gepirone, tandospirone) is that their major metabolite, 1-PP, is a potent NE alpha2 receptor antagonist, a property they share with Remeron.
>
> - Scott

Why would a drug work as an augmenter, but not as a stand-alone antidepressant? If it helps at all, shouldn't it show some efficacy on its own?


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poster:mtdewcmu thread:931601
URL: http://www.dr-bob.org/babble/20091227/msgs/931709.html