Posted by SLS on December 31, 2009, at 2:24:29
In reply to Re: Tandospirone, posted by mtdewcmu on December 30, 2009, at 23:10:27
> > Tandospirone and gepirone are both azapirones that act as 5-HT1a partial agonists. I have always thought that gepirone would make a better augmenter of antidepressants than it is a monotherapeutic tool to treat depression. The same might be true of tandospirone. One thing that is rarely mentioned about these drugs (buspirone, gepirone, tandospirone) is that their major metabolite, 1-PP, is a potent NE alpha2 receptor antagonist, a property they share with Remeron.
> >
> > - Scott
>
> Why would a drug work as an augmenter, but not as a stand-alone antidepressant? If it helps at all, shouldn't it show some efficacy on its own?It is like adding lithium to a tricyclic in unipolar depression. By itself, lithium is usually inert.
- Scott
poster:SLS
thread:931601
URL: http://www.dr-bob.org/babble/20091227/msgs/931734.html