Posted by linkadge on May 21, 2010, at 18:45:11
In reply to Re: Immipramine Causes Natural Endorphins to Drop » linkadge, posted by bulldog2 on May 21, 2010, at 15:20:28
>The guy makes the conclusions in the following >paragraph. He does state the natural feel good >transmitters would drop with immipramine. That >was his conclusion from the study.
Yes, that was *his* conclusion from the study. This was not the conclusion of the study. There are likely other metabolic pathways for opiates. An alteration in one metabolic pathway does not really predict the actity of the substrate.
>What is flawed in his logic? Here is >paragraph.You state the opposite might actually >be the case.
Well you just can't conclude one thing from the other. Did the imipramine directly cause the endopeptidase to increase, or did the imipramine cause endorpins to rise which was compensated for by the increases in the endopeptidase. Even though one metabolic pathway for a neurotransmitter increases, does not necessarily mean that the neurotransmitter becomes depleted. It could simply be a result of enhanced opiate turnover. Perhaps opiate release that is enhanced by the imipramine with a corresponding increase in a metabolic pathway (i.e. increases functional activity of the opaites). If you take an SSRI, it has been shown that monoamine oxidase will increase. But, just because monoamine oxidase increases as a result of taking an SSRI, doesn't mean that serotonin levels are dropping as a result of taking an SSRI.
NRI's have an ability to prolong the activity of endorphins. So perhaps, the endopepidase is simply increasing as a homeostatic mechanism to correct for the inhibition a seperate metabolic pathway.
A seperate note. Some studies link *higher* opiate activity to depression! This study is entitled "overactive endorphin system linked to depression"
http://www.anxietyinsights.info/overactive_brain_endorphin_system_linked_to_depression.htm
So, perhaps the clinical effect is in part mediated by a decrease in endorphin levels.
The point I am trying to make, is the net effect is whether the drug works for you or not. Don't get all hung up on what brain chemical the drug tweaks, this is really inconsequential. Drugs tweak a lot of brain chemicals. What is the net effect for you?
Sure, if *you* feel crappy on the drug, then it is not right for you. Don't worry the shortsighted conlcusions that some nimrod comes to.
Linkadge
poster:linkadge
thread:948058
URL: http://www.dr-bob.org/babble/20100514/msgs/948227.html