Posted by linkadge on June 28, 2010, at 14:08:43
In reply to Re: The biology of depression: Wolkowitz brings hope, posted by Rosy Crucifiction on June 27, 2010, at 22:56:09
Well, the stress model of major depression is still only theoretical. It may not explain why some of us experience recurrent depression in the absence of significant life stress.
In the flinders animal model of depression, hippocampal neurogenesis is actually increased. In this model, theraputic nortriptyline or citalopram actually lowers hippocampal neurogenesis. Also, in animal models, escitalopram has no effect on hippocampal neurogensis.
Also, this does not explain why ECT or sleep deprivation can induce rapid improvement in depression. Theres not enough time here for new brain cells to mature and become funtioning.
Linkadge
poster:linkadge
thread:952373
URL: http://www.dr-bob.org/babble/20100628/msgs/952530.html