Posted by SLS on June 28, 2010, at 14:23:08
In reply to Re: The biology of depression: Wolkowitz brings hope, posted by linkadge on June 28, 2010, at 14:08:43
> Well, the stress model of major depression is still only theoretical. It may not explain why some of us experience recurrent depression in the absence of significant life stress.
>
> In the flinders animal model of depression, hippocampal neurogenesis is actually increased. In this model, theraputic nortriptyline or citalopram actually lowers hippocampal neurogenesis. Also, in animal models, escitalopram has no effect on hippocampal neurogensis.
>
> Also, this does not explain why ECT or sleep deprivation can induce rapid improvement in depression. Theres not enough time here for new brain cells to mature and become funtioning.
>
> Linkadge
When you observe ultra-rapid cyclicity or ultra-dian cyclicity in person, you realize just how quickly and completely brain function can change. There might as well be a switch. There would seem to be no room for a neurogenesis explanation for this phenomenon. Do you think such a switch might lie in the cingulate cortex?
- Scott
The measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:952373
URL: http://www.dr-bob.org/babble/20100628/msgs/952531.html