Posted by Brainbeard on June 29, 2010, at 17:44:50
In reply to Re: what is 50mg anafranil = to as SSRI ? » Brainbeard, posted by SLS on June 29, 2010, at 7:06:07
> > With 50mg clomipramine, you would have about 80%+ saturation of serotonin receptors.
>
> Is that transporter inhibition? That's interesting, because most people don't get much from clomipramine until they get up to 100-150mg, with a maximum recommended dosage being 250mg. Where can I find out more about the 80% saturation number?
>
>
> - ScottI thought Preskorn (http://www.preskorn.com/books/ssri_s3.html) talked about that, but it turns out he's talking about 80% inhibition of the transporters.
Anyway, only 10mg of clomipramine is equivalent to 50mg of fluvoxamine as for serotonin occupancy*, so you would expect that about 50mg of clomipramine would already yield some pretty impressive SRI.
Raising the dose will favour the noradrenergic metabolite more and more, since this has a longer half-life. So for higher doses, it may really be the noradrenergic boost that is important, plus all the bonuses that come with TCA therapy.
* http://archpsyc.ama-assn.org/cgi/reprint/60/4/386.pdf
Current meds: sertraline 200mg; amitriptyline 50mg; melatonin 0.3mg. PRN: diazepam (Valium) 2.5-10mg.
poster:Brainbeard
thread:952518
URL: http://www.dr-bob.org/babble/20100628/msgs/952643.html