Posted by linkadge on October 15, 2010, at 16:47:26
In reply to Re: Study: Reboxetine found ineffective,may be harmful » Jay_Clockwork_Angels, posted by SLS on October 15, 2010, at 5:04:48
Tyrosine hydroxylase (the enzyme which synthesizes norepinephrine) is elevated in depression.
Depression (especially that associated with stress/anxiety) has been linked to an overactivity of the central noradrenergic system.
The following article discusses how paroxetine increases activity of the locus coeruleus in juvenile rats - a model of paroxetine induced suicidality (?)
see: http://www.ncbi.nlm.nih.gov/pubmed/20357759
"Both clinical and preclinical evidences indicate that the principal noradrenergic cell group in the brain, the locus coeruleus (LC), is overactive in depressives and that, conversely, effective AD treatments decrease the activity of LC neurons. We report here that short-term (2 and 4 days) administration of PAR produces an increase in the activity of LC neurons (spontaneous firing rate and sensory-evoked responses) in young rats, contrary to the 'therapeutic' decrease in activity typically observed in adult rats."
poster:linkadge
thread:965563
URL: http://www.dr-bob.org/babble/20101009/msgs/965865.html