Posted by linkadge on October 16, 2010, at 9:17:35
In reply to Re: Study: Reboxetine found ineffective,may be harmful » linkadge, posted by SLS on October 16, 2010, at 5:23:33
>What properties of desipramine do you think >contribute to its antidepressant effect?
Of course, I don't really know anything for sure, but based on some reading the TCAs have other common effects including:
- Monoamine receptor blockade (5-ht2,3,7 receptor antagonists have antidepressant effects)
- Increased sensitivty of limbic dopamine d2/d3 receptors (even surmontil)
- weak-moderate MAOI activity (maoa < maob)
- opioid activity, kappa, delta, mu, etc
- ion channel blockade
- muscarinic (esp. m1 antagonism)
- direct interaction with HPA axis (?)
- modification of phospholipid (cellular) activity
- sigma receptor agonism
- TRK-a/b agonism (amitriptyline)
- weak gaba transporter inhibition
- metabolite of desipramine is more serotonin selective
- NMDA receptor antagonism (synergy with sigma agonism)
- dopamine reuptake inhibition (stronger with desipramine than other tcas)
- antihistamine effects (histamine activity is overactive in some animal models of depression)
- interaction with adenosine receptors (TCAs potentiate the activity of adenosine through inhibition of the adenosine transporter - relavance to anxiety disorders)
- other, more fundamental properties ?
Linkadge
poster:linkadge
thread:965563
URL: http://www.dr-bob.org/babble/20101009/msgs/965950.html