Posted by Tomatheus on November 17, 2010, at 0:35:17
In reply to Re: Anyone have exp with both Parnate and Cymb/Effexor, posted by morgan miller on November 17, 2010, at 0:01:44
> Why not try Nardil again and try to make sure you get the good stuff?
One thing that would concern me about taking Nardil again would be that the potential for getting another bad batch would still be there. I don't really want to take a medication that's not going to be reliable from one batch to the next, and I'm not sure how I'd be able to ensure that I'd keep getting good batches of Nardil.
Another concern of mine is that Nardil probably wouldn't work the same for me as it used to, even if I can get good batches of the medication all the time. Since I developed psychotic symptoms, my responses to medications have changed drastically. For some reason, I don't get the same responses out of the U.K. Goldshield tranylcypromine or enteric-encapsulated Marplan that I used to. I think that the reason for this may be that the juices in my stomach are somehow degrading the enteric coatings of the two medications that I just mentioned and are consequently breaking down the active ingredients before they're able to get absorbed into the bloodstream. I say this because after I took enteric-encapsulated Marplan last, I heard it dissolve in my stomach within minutes of taking it. Enteric coatings (and capsules) should protect medications until they reach the small intestine, and I don't think that medications get past the stomach in a matter of minutes. What I mentioned about the U.K. Goldshield tranycypromine and enteric-encapsulated Marplan is also true of SAMe -- it no longer works for me -- and SAMe is another enteric-coated product. Considering that I needed to basically give Nardil an enteric coating to allow it to work for more than two weeks, I have strong doubts that Nardil would be able to do for me what it once did.
A third concern that I have about taking Nardil again is that if it does work, it may make my psychotic symptoms worse. Among Nardil's mechanisms of action is the inhibition of monoamine oxidase B, and enzyme that has actually been shown to be low in the platelets of schizophrenics. I might still be willing to try Nardil again if this were my only concern, but coupled with my other concerns, it doesn't seem like the best idea.
Another reason why I haven't tried Nardil again is that my current psychiatrist hasn't indicated that he'd like to prescribe it. I guess I would need to ask him to find out if he's truly willing to prescribe Nardil, but he knows that Nardil is the only medication to bring me into remission for more than a few days and hasn't shown any signs of wanting to prescribe it, so that's not a good sign.
Finally, and most importantly, I don't particularly want to take Nardil again because I'm reasonably satisfied with the way that my current medications and supplements are treating my depression. I would say that since adding kanna to my regimen that my depressive symptoms, on average, are in 70 percent remission. Is it the relief that I had when I was taking Nardil? No. However, my depressive symptoms are more or less manageable now, and I don't want to stop something that's working for something that very well might not work and might make me more psychotic.
Tomatheus
Diagnosed with schizoaffective disorder. Currently taking 5 mg Abilify, 12.5 mg Lamictal, 2.25 mg Hydergine, and four supplements.
poster:Tomatheus
thread:969802
URL: http://www.dr-bob.org/babble/20101107/msgs/970562.html