Posted by Conundrum on April 2, 2011, at 5:09:50
In reply to Re: From which dose venlafaxine is stimulant?, posted by linkadge on April 1, 2011, at 20:27:46
> Thats what I don't understand. Remeron is not really dual acting (at least in the way effexor is). I also continually see people quit remeron for lack of sustained efficacy.
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> The statistical methods for comparing antidepressant efficacy is highly controversial.
> Drug A might beat B and B might beat C, yet C also beats A. It depends on what weighting factors you give to efficacy and tollerability in your overall rating. It also depends on what studies you include and how you rate the study's overall believability. I.e. if you remove studies funded by the drug company, would you get the same results? Yes, escitalopram is rated highly, but most of the positive studies are industry funded.
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> LinkadgeThat is a good point. If the studies used were those funded by drug companies then it seems that the companies that did the greatest number of studies would come out on top. It would be interesting to see if that was the case.
Anyway regarding remeron, for me it was one of the few drugs that had any effect, but it did poop out in record time. Pristiq and prozac have been the only drugs that have had any effect on me. Pristiq is an active metabolite of venlafaxine so perhaps there is something to this study. By dual acting, I meant the drug is antagonist in the serotonergic and adrenergic systems. However one could argue Zoloft is a dual acting drug.
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual anhedonia. )
Country:USA
Currently taking 2.5 mg prozac, Multi B vitamin
poster:Conundrum
thread:981641
URL: http://www.dr-bob.org/babble/20110321/msgs/981705.html