Posted by desolationrower on April 7, 2011, at 17:28:14
In reply to Re: For serious 5ht2C-antagonism, LOW doses are needed, posted by Brainbeard on April 7, 2011, at 15:06:16
> >I'm not convinced about the 'only need a little antagonism for a significant effect'.
>
> I'm not convinced of your counter-arguments either, mostly because I don't understand them. :)
>
> Agomelatine is an effective 5HT2C-antagonist, right? Interestingly, the Ki value for agomelatine's binding affinity to the 5HT2C receptor is way higher than Prozac's: it's 710nM! (http://www.medicographia.com/html/static/html/issues/article_latest.asp?page=issues/99/art_10/p_2) This means that agomelatine's binding affinity for the 5HT2C-receptor is WWWWWWAAAYYYYYYYYYYY lower than fluoxetine's. It'd better be true that only a little antagonism of 5HT2C-receptors yields significant effects, or agomelatine's supposed 5HT2C-antagonism is a scam.i hadn't seen those values before.
its more likely that the regular dose of agomelatine is just acting to induce deep sleep
-d/r
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:982000
URL: http://www.dr-bob.org/babble/20110406/msgs/982206.html