Posted by SLS on April 8, 2011, at 5:11:33
In reply to Re: For serious 5ht2C-antagonism, LOW doses are needed, posted by mtdewcmu on April 7, 2011, at 20:48:20
> The absolute value for Ki doesn't matter.
I think it might. One example would be the tendency for Abilify to reduce the effectiveness of Seroquel and perhaps other APs with a low affinity for D2 receptors. D2 binding is quite a bit higher for Abilify, which then would act as a D2 partial agonist. Abilify competes with Seroquel and wins.
> It only matters what the Ki is relative to the Ki for the other receptors. You can compensate for a low binding affinity by increasing the dose, unless side effects or toxicity become significant.
I see what you are saying. Using my example above, I have seen Abilify necessitate an increase in the dosage of Seroquel from 200 mg to 900mg. Discontinuing Abilify allowed for a return to a lower dosage of Seroquel.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:982000
URL: http://www.dr-bob.org/babble/20110406/msgs/982233.html